ANALOGS OF FEXARAMINE AND METHODS OF MAKING AND USING

embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeuticall...

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Bibliographische Detailangaben
Hauptverfasser: Baiga, Thomas J, Suh, Jae Myoung, Liddle, Christopher, Downes, Michael, Atkins, Annette, Fang, Sungsoon, Yu, Ruth T, Keana, John F.W, Evans, Ronald M
Format: Patent
Sprache:eng
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Zusammenfassung:embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.