NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the a...

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Bibliographische Detailangaben
Hauptverfasser: Loun, Bounthon, Anderson, Annaliesa Sybil, Farley, John Erwin, Harris, Shannon Lea, Zlotnick, Gary Warren, Jansen, Kathrin Ute, Perez, John Lance, Khandke, Lakshmi, Jones, Thomas Richard, Arumugham, Rasappa Gounder, Fletcher, Leah Diane
Format: Patent
Sprache:eng
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Zusammenfassung:In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.