CHIMERIC ANTIGEN RECEPTORS AGAINST SENESCENT CELLS AND USES THEREOF

CHIMERIC ANTIGEN RECEPTORS AGAINST SENESCENT CELLS AND USES THEREOF

The invention relates to a chimeric antigen receptor (CAR) comprising directed to at least one senescent cell-associated antigen, preferably to DEP1 and/or DPP4; including bispecific CAR, bispecific antibodies, and isolated immune cell population expressing the same. It also relates to uses and meth...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mathieu, Thierry, Ogrunc, Müge
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a chimeric antigen receptor (CAR) comprising directed to at least one senescent cell-associated antigen, preferably to DEP1 and/or DPP4; including bispecific CAR, bispecific antibodies, and isolated immune cell population expressing the same. It also relates to uses and methods for treating, preventing or alleviating senescence-related diseases or disorders, or for depleting and/or killing senescent cells.