STAIN NORMALIZATION FOR AUTOMATED WHOLE-SLIDE IMAGE CLASSIFICATION

Techniques for stain normalization image processing for digitized biological tissue images are presented. The techniques include obtaining a digitized biological tissue image; applying to at least a portion of the digitized biological tissue image an at least partially computer implemented convolutional neural network trained using a training corpus including a plurality of pairs of images, where each pair of images of the plurality of pairs of images includes a first image restricted to a lightness axis of a color space and a second image restricted to at least one of: a first color axis of the color space and a second color axis of the color space, such that the applying causes an output image to be produced; and providing the output image.