NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK-also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and a...

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Hauptverfasser: MACLEOD, Calum, MEERPOEL, Lieven, QUEROLLE, Olivier Alexis Georges, GROSS, Gerhard Max, STANSFIELD, Ian, JACOBY, Edgar, MANN, Samuel Edward, HYND, George, PONCELET, Virginie Sophie, KULAGOWSKI, Janusz Jozef, GREEN, Simon Richard
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creator MACLEOD, Calum
MEERPOEL, Lieven
QUEROLLE, Olivier Alexis Georges
GROSS, Gerhard Max
STANSFIELD, Ian
JACOBY, Edgar
MANN, Samuel Edward
HYND, George
PONCELET, Virginie Sophie
KULAGOWSKI, Janusz Jozef
GREEN, Simon Richard
description The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK-also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
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