SYSTEMS AND METHODS FOR MICROBIOME BASED SAMPLE CLASSIFICATION

SYSTEMS AND METHODS FOR MICROBIOME BASED SAMPLE CLASSIFICATION

The classification of disease status based on the stool microbiome of the subject, or other relevant DNA, is a challenging field with a lack of accurate diagnostics. Accordingly, the inventors have developed systems and methods which accurately classify the disease status of a subject using a k-mer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MANOHARAN, Arun Prasad, PROFFITT, Eric Shaun
Format: Patent
Sprache:eng
Schlagworte:
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Beschreibung
Zusammenfassung:The classification of disease status based on the stool microbiome of the subject, or other relevant DNA, is a challenging field with a lack of accurate diagnostics. Accordingly, the inventors have developed systems and methods which accurately classify the disease status of a subject using a k-mer based algorithm for processing a subject's microbial DNA. In some examples, this includes using a logistic regression algorithm trained with L1-regularization to process DNA read derived k-mers from a subject's sample.