TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM

TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM

A process of production of trazodone or trazodone hydrochloride diet comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heati...

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Bibliographische Detailangaben
Hauptverfasser: MARCHETTI, Marcello, BIONDI (Deceased), Giuseppe, IACOANGELI, Tommaso, CIOTTOLI, Giovanni Battista
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A process of production of trazodone or trazodone hydrochloride diet comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, a pharmaceutical composition comprising said trazodone hydrochloride.