Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof

Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof

In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloa...

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Bibliographische Detailangaben
Hauptverfasser: DASHTI-POUR, Mohadeseh, HAYWARD, John, NASRI, Sarah, TRANT, John Frederick, TAIMOORY, Seyedeh Maryamdokht, MEISTER, Daniel, CHIFOR, Anthony Emanuel
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.