METHODS OF DETECTION AND TREATMENT OF HYPER TRANSCRIPTION DISEASES

Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Ataxia Telangiectasia and Rad3 related Serine/Threonine protein kinase and an inhibitor of poly (ADP-ribose) polymerase (1). Described here are methods of treatment o...

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Bibliographische Detailangaben
Hauptverfasser:	GORTHI, Aparna, BISHOP, Alexander James, LAWRENCE, Liesl A, ROMERO, July Carolina
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Ataxia Telangiectasia and Rad3 related Serine/Threonine protein kinase and an inhibitor of poly (ADP-ribose) polymerase (1). Described here are methods of treatment of hyper transcription diseases in patients by administering a combination of an inhibitor of Checkpoint kinase (1) and an inhibitor of poly (ADP-ribose) polymerase (1). Also provided are methods for diagnosing hyper transcription diseases in a subject by analyzing a tissue sample from the subject for changes in the plurality of R-loops or the phosphorylation levels of RNA polymerase II.