POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

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Hauptverfasser: WON, Walter S, LI, Jie Jack, AAY, Naing N, KOLTUN, Elena S, BLANK, Brian R, TZITZILONIS, Christos, PITZEN, Jennifer, BUCKL, Andreas, WANG, Gang, JOGALEKAR, Ashutosh S, MELLEM, Kevin T, GILL, Adrian Liam, CREGG, James Joseph
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator WON, Walter S
LI, Jie Jack
AAY, Naing N
KOLTUN, Elena S
BLANK, Brian R
TZITZILONIS, Christos
PITZEN, Jennifer
BUCKL, Andreas
WANG, Gang
JOGALEKAR, Ashutosh S
MELLEM, Kevin T
GILL, Adrian Liam
CREGG, James Joseph
description The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
format Patent
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
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