POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

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Bibliographische Detailangaben
Hauptverfasser:	WON, Walter S, LI, Jie Jack, AAY, Naing N, KOLTUN, Elena S, BLANK, Brian R, TZITZILONIS, Christos, PITZEN, Jennifer, BUCKL, Andreas, WANG, Gang, JOGALEKAR, Ashutosh S, MELLEM, Kevin T, GILL, Adrian Liam, CREGG, James Joseph
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.