FLUORESCENT MEROCYANINE DYES, ASSOCIATED CONJUGATES AND METHODS

FLUORESCENT MEROCYANINE DYES, ASSOCIATED CONJUGATES AND METHODS

Described are fluorescent merocyanine dyes useful as labels for the detection of target molecules. The dyes may be conjugated to a binding agent, such as an aptamer, or used in label-free assays. An exemplary merocyanine dye termed 4QI based on its 4-methylquinoline and indole heterocycle components...

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Bibliographische Detailangaben
Hauptverfasser: Gray, Micaela, Chung, Andrew, Deore, Prashant, Manderville, Richard, Van Riesen, Abigail
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Described are fluorescent merocyanine dyes useful as labels for the detection of target molecules. The dyes may be conjugated to a binding agent, such as an aptamer, or used in label-free assays. An exemplary merocyanine dye termed 4QI based on its 4-methylquinoline and indole heterocycle components is also described as well as phosphoramidite compounds and methods for the detection of targets.