SINGLE MOLECULE DETECTION OR QUANTIFICATION BY DNA NANOTECHNOLOGY IN MICROWELLS

The invention relates to a method and a DNA nanostructure for detecting a target structure. The invention relates in particular to a DNA nanostructure, which, by skillful selection of the shape of the DNA nanostructure and the placement of marker molecules fastened thereon, ensures a preferably line...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Woehrstein, Johannes, Grabmayr, Heinrich
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a method and a DNA nanostructure for detecting a target structure. The invention relates in particular to a DNA nanostructure, which, by skillful selection of the shape of the DNA nanostructure and the placement of marker molecules fastened thereon, ensures a preferably linear dependence on the number of marker molecules and measurement signal, independent of the local arrangement of a plurality of such DNA nanostructures. The invention further relates to using said DNA nanostructures and other nano reporters, preferably in combination with adapters specifically binding to target molecules, in a method for the preferably simultaneous quantification of a plurality of target molecules, by means of a multiplex method. The method relates in particular to a single cell analysis.