DNA-BINDING DOMAIN OF CRISPR SYSTEM, NON-FUCOSYLATED AND PARTIALLY FUCOSYLATED PROTEINS, AND METHODS THEREOF

The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Shor...

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Hauptverfasser:	M, Pavithra, M, Sathyabalan, Prasad, Bhargav, Thanigaivel, Aswini, Kurup, Anisha, Rodrigues, Kavitha Iyer, Pendse, Rajeshwari, Pathak, Prabhat Kumar, Nair, Karthika, Bhattacharjee, Sanghamitra, Shenoy, Bharath R, Unnikrishnan, Divya, Rao, Sahana Bhima, K, Veeresha, Chatterjee, Sohang, B.M., Yogendra Manjunath, Srinivasan, Sankaranarayanan, Halan, Vivek, D, Pravin Kumar, N, Bairavabalakumar, Maliwalave, Amol, Maity, Sunit, Hora, Anuradha, Hazarika, Jahnabi, Ghosh, Maloy
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.