STAGED-RETENTION METHOD FOR UPSTREAM PRODUCTION OF BIOMACROMOLECULES, PRODUCTION MODULE USED THEREIN AND APPLICATION THEREOF IN PRODUCTION

STAGED-RETENTION METHOD FOR UPSTREAM PRODUCTION OF BIOMACROMOLECULES, PRODUCTION MODULE USED THEREIN AND APPLICATION THEREOF IN PRODUCTION

The present disclosure provides a staged-retention method for upstream production of biomacromolecules, a production module used therein, and an application of the method/module in the industrial production of polypeptides, fusion proteins and immunoglobulin molecules. The method of the present disc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG, Jianqing, LIN, Jun, LI, Zicai, AN, Mingyan, LI, Minzhu, XU, Shuiqing, DUAN, Qingtang, KAN, Steven, Z, ZHOU, Joe
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present disclosure provides a staged-retention method for upstream production of biomacromolecules, a production module used therein, and an application of the method/module in the industrial production of polypeptides, fusion proteins and immunoglobulin molecules. The method of the present disclosure can effectively improve the upstream production efficiency, yield and purity in the large-scale production of a recombinant protein.