STABLE DITHIZONE SOLUTIONS AND FORMULATIONS AND METHODS FOR THEIR USE

STABLE DITHIZONE SOLUTIONS AND FORMULATIONS AND METHODS FOR THEIR USE

An optimized Dipheylthiocarbazone or Dithizone (DTZ) solution was developed with preferred physical and chemical properties to characterize human islets and insulin producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of...

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Bibliographische Detailangaben
Hauptverfasser: QI, Meirigeng, VALIENTE, Luis, AL-ABDULLAH, Ismail H, KHIATAH, Bashar
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Zusammenfassung:An optimized Dipheylthiocarbazone or Dithizone (DTZ) solution was developed with preferred physical and chemical properties to characterize human islets and insulin producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals and cell and tissue types found to be robust for identifying these cells. The iDTZ, through high transition zinc binding, concentrated in insulin producing cells could also be used to delineate zinc levels in tissue and liquid samples.