FOXP3-BINDING PEPTIDES AND USES THEREOF

The present invention provides peptides of general formula (I) and salts thereof, wherein: R1 and R2, taken together, form a birradical linker; and R2′ is hydrogen; or, alternatively, R1 is selected from hydrogen, -C(═O)-CH2-NH-C(═O)-(C1-C5)alkyl, and -C(═O)-(C1-C20)alkyl; one of R2 and R2′ is hydro...

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Bibliographische Detailangaben
Hauptverfasser:	LASARTE SAGASTIBELZA, Juan José, CASARES LAGAR, Inés Noelia, OYARZABAL SANTAMARINA, Julen, RABAL GRACIA, Maria Obdulia, LOZANO MOREDA, Teresa
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides peptides of general formula (I) and salts thereof, wherein: R1 and R2, taken together, form a birradical linker; and R2′ is hydrogen; or, alternatively, R1 is selected from hydrogen, -C(═O)-CH2-NH-C(═O)-(C1-C5)alkyl, and -C(═O)-(C1-C20)alkyl; one of R2 and R2′ is hydrogen and the other is selected from -C(═O)NR3R4, and -C(═O)OH; and R3 and R4 are same or different and are selected from hydrogen and (C1-C10)alkyl.These peptides are highly efficient in binding and inhibiting FoxP3, being efficient in inhibiting and blocking Treg cell functionality, which make them useful in the treatment of cancer.The present invention also provides constructs comprising the peptide of formula (I) as well as combinations comprising the peptide of formula (I), the construct or both.