COMPOSITION AND DEVICE FOR DELIVERY OF ACTIVE AGENTS TO SKIN SURFACES

A transdermal delivery device (10, 10′) includes at least one of a backing layer (14) and a removable release liner (16). An active layer (12, 12′) is supported by the backing layer and/or release liner. The active layer includes a polymer matrix, a therapeutically/cosmetically effective amount of a...

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Bibliographische Detailangaben
Hauptverfasser:	Beckert, Thomas, Stehle, Jochen, Thut, Anja, Ramadan, Mohamed Hussein, Nejad, Hossein Birjandi, Tang, Qiong, Marchant, Nancy S, Heinzelmann, Jürgen
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	A transdermal delivery device (10, 10′) includes at least one of a backing layer (14) and a removable release liner (16). An active layer (12, 12′) is supported by the backing layer and/or release liner. The active layer includes a polymer matrix, a therapeutically/cosmetically effective amount of an active agent dispersed in the polymer matrix, and a pressure sensitive adhesive, incorporated in the polymer matrix and/or adhered thereto. The polymer matrix includes a thermoplastic polyurethane polymer and optionally, a poly(meth)acrylate polymer. The thermoplastic polyurethane polymer includes the reaction product of: a first polyether polyol A having a molecular weight of at least 3000 daltons and/or a second polyether polyol B having a molecular weight of no more than 2500 daltons; a third polyol C having a molecular weight of up to 800 daltons and/or a chain extender; a polyisocyanate; and optionally a catalyst.