HIGHLY EFFICIENT ENZYMATIC PROCESS TO PRODUCE (R)-3-QUINUCLIDINOL

HIGHLY EFFICIENT ENZYMATIC PROCESS TO PRODUCE (R)-3-QUINUCLIDINOL

The present invention relates to enzymatic reduction of 3-quinuclidinone to (R)-3-quinuclidinol (Scheme I), by reacting 3-quinuclidinone with a variant of ketoreductase enzyme derived from Rhodotorula rubra. The invention also relates to enzymatically produced (R)-3-quinuclidinol wherein the substra...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: UDIPI, Minal P, KUMAR, Sudeep, SATHE, Dhananjay, DAS, Arijit, ASHOK, Maitreyi, D'SOUZA, Conchita, KATDARE, Mamata
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to enzymatic reduction of 3-quinuclidinone to (R)-3-quinuclidinol (Scheme I), by reacting 3-quinuclidinone with a variant of ketoreductase enzyme derived from Rhodotorula rubra. The invention also relates to enzymatically produced (R)-3-quinuclidinol wherein the substrate loading capacity of the enzyme is not less than 100g/L.