HYDROPHOBIC ION PAIRING AND FLASH NANOPRECIPITATION FOR FORMATION OF CONTROLLED-RELEASE NANOCARRIER FORMULATIONS

HYDROPHOBIC ION PAIRING AND FLASH NANOPRECIPITATION FOR FORMATION OF CONTROLLED-RELEASE NANOCARRIER FORMULATIONS

Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are prese...

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Bibliographische Detailangaben
Hauptverfasser: PRUD'HOMME, Robert K, RUMMANEETHORN, Paradorn, RISTROPH, Kurt D, PINKERTON, Nathalie M, LU, Hoang D
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.