TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF BREAST CANCER

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast canc...

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Bibliographische Detailangaben
Hauptverfasser:	Zhu, Ping, Zheng, Guo Zhu, Bock, Mark, Hao, Ming-Hong, Samarakoon, Thiwanka, Puyang, Xiaoling, O'Shea, Morgan, Larsen, Nicholas, Korpal, Manav, Samajdar, Susanta, Mitchell, Lorna Helen, Smith, Peter Gerard, Wang, John, Rioux, Nathalie, Prajapati, Sudeep, Reynolds, Dominic, Nyavanandi, Vijay Kumar
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.