ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES

Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reactio...

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Hauptverfasser:	SAMS, Christian Klarner, ANDERSEN, Anne Lee, PEDERSEN, Henrik, HOLTMANN, Anette, FRESKGARD, Per-Ola, NØRREGAARD-MADSEN, Mads, GODSKESEN, Michael Anders, OLSEN, Eva Kampmann, GOULIAEV, Alex Haahr, KALDOR, Ditte Kievsmose, HUSEMOEN, Gitte Nystrup, FRANCH, Thomas, PETERSEN, Lene, THISTED, Thomas, JENSEN, Kim Birkebæk, FELDING, Jakob, GLAD, Sanne Schrøder, JAKOBSEN, Søren Nyboe, GOLDBECH, Anne, SØRENSEN, Anders Malling, SLØK, Frank Abildgaard, LUNDORF, Mikkel Dybro, NEVE, Søren, KRONBORG, Tine Titilola Akinleminu, HANSEN, Anders Holm, DOLBERG, Johannes, de LEON, Daen
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).