METHOD FOR PRODUCING MULTISPECIFIC ANTIBODIES

METHOD FOR PRODUCING MULTISPECIFIC ANTIBODIES

Herein are provided a method for producing a multispecific antibody comprising the steps of providing a mammalian cell expressing the antibody, transfecting said mammalian cell with an expression vector comprising an expression cassette encoding a polypeptide of the antibody that has a domain crosso...

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Bibliographische Detailangaben
Hauptverfasser: KETTENBERGER, Hubert, GOEPFERT, Ulrich, PAUL, Wolfgang, SEEBER, Stefan, OSTERLEHNER, Andrea
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Herein are provided a method for producing a multispecific antibody comprising the steps of providing a mammalian cell expressing the antibody, transfecting said mammalian cell with an expression vector comprising an expression cassette encoding a polypeptide of the antibody that has a domain crossover, cultivating the transfected cell and recovering the antibody from the cell or the cultivation medium and thereby producing the multispecific antibody.