NEUTRALIZING ANTI-INFLUENZA B ANTIBODIES AND USES THEREOF

NEUTRALIZING ANTI-INFLUENZA B ANTIBODIES AND USES THEREOF

The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of bindin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCAULIFFE, Josephine Mary, BENJAMIN, Ebony, WACHTER, Leslie, ZHU, Qing, CORTI, Davide, LANZAVECCHIA, Antonio, KALLEWAARD-LELAY, Nicole, YUAN, Andy
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Beschreibung
Zusammenfassung:The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.