PERIODONTAL DISEASE STRATIFICATION AND USES THEREOF

Described herein are methods of classifying periodontal patients and individual teeth. For example, disclosed is a method of diagnosing periodontal disease and/or risk of tooth loss in a subject that involves classifying teeth into one of 7 classes of periodontal disease. The method can include the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Moss, Kevin Lee, Offenbacher, Steven, Morelli, Thiago, Beck, James Douglas
Format:	Patent
Sprache:	eng
Schlagworte:	DIAGNOSIS HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA HUMAN NECESSITIES HYGIENE IDENTIFICATION INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEDICAL OR VETERINARY SCIENCE PHYSICS SURGERY
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Beschreibung
Zusammenfassung:	Described herein are methods of classifying periodontal patients and individual teeth. For example, disclosed is a method of diagnosing periodontal disease and/or risk of tooth loss in a subject that involves classifying teeth into one of 7 classes of periodontal disease. The method can include the step of performing a dental examination on a patient and determining a periodontal profile class (PPC). The method can further include the step of determining for each tooth a Tooth Profile Class (TPC). The PPC and TPC can be used together to generate a composite risk score for an individual, which is referred to herein as the Index of Periodontal Risk (IPR). In some embodiments, each stage of the disclosed PPC system is characterized by unique single nucleotide polymorphisms (SNPs) associated with unique pathways, identifying unique druggable targets for each stage.