FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE

FUSION PROTEIN CONSTRUCTS FOR COMPLEMENT ASSOCIATED DISEASE

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Fur...

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Bibliographische Detailangaben
Hauptverfasser: STOREK, MICHAEL, CARAVELLA, JUSTIN ANDREW, HUANG, CHENG RAN, CURTIS, MICHAEL STEVEN, STARK, ELLEN GARBER, TAYLOR, FREDERICK ROBBINS, KALLED, SUSAN L, VIOLETTE, SHELIA MARIE, FAHNOE, KELLY C, HOLERS, VERNON MICHAEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.