PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS

PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Therrien, Eric, Dahlgren, Markus Kristofer, Greisman, Jack Benjamin, Lescarbeau, André, Kelley, Elizabeth H, Murcko, Mark Andrew, Tang, Yong, Pierce, Levi Charles Thomas, Taylor, Alexander M, Maragakis, Paul, Shortsleeves, Kelley C, Giordanetto, Fabrizio, DiPietro, Lucian V, Walters, W. Patrick, Bhat, Sathesh
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.