4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT

4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT

wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kawakami, Hiroshi, Wamaki, Shuichi, Satoh, Motohide, Itoh, Yoshiharu, Motomura, Takahisa, Matsuzaki, Yuji, Aramaki, Hisateru, Watanabe, Wataru, Shinkai, Hisashi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.