SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders...

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Hauptverfasser: Therrien, Eric, Dipietro, Lucian V, Dahlgren, Markus Kristofer, Greisman, Jack Benjamin, Kelley, Elizabeth H, Lescarbeau, André, Murcko, Mark Andrew, Pierce, Levi Charles Thomas, Maragakis, Paul, Taylor, Alexander M, Shortsleeves, Kelley C, Giordanetto, Fabrizio, Walters, W. Patrick, Bhat, Sathesh
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creator Therrien, Eric
Dipietro, Lucian V
Dahlgren, Markus Kristofer
Greisman, Jack Benjamin
Kelley, Elizabeth H
Lescarbeau, André
Murcko, Mark Andrew
Pierce, Levi Charles Thomas
Maragakis, Paul
Taylor, Alexander M
Shortsleeves, Kelley C
Giordanetto, Fabrizio
Walters, W. Patrick
Bhat, Sathesh
description The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF
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