SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Therrien, Eric, Dipietro, Lucian V, Dahlgren, Markus Kristofer, Greisman, Jack Benjamin, Kelley, Elizabeth H, Lescarbeau, André, Murcko, Mark Andrew, Pierce, Levi Charles Thomas, Maragakis, Paul, Taylor, Alexander M, Shortsleeves, Kelley C, Giordanetto, Fabrizio, Walters, W. Patrick, Bhat, Sathesh
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.