HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH
The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodie...
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| creator | SOLOVIEV, Valeriy Vladimirovich NEMANKIN, Timofey Aleksandrovich MOROZOV, Dmitriy Valentinovich CHERNYKH, Yulia Sergeevna GONCHAROVA, Olga Vladimirovna CHERNOVSKAYA, Tatyana Veniaminovna SOFRONOVA, Ekaterina Vladimirovna ULITIN, Andrey Borisovich IVANOV, Roman Alexeevich EVDOKIMOV, Stanislav Rudolfovich EKIMOVA, Victoria Mikhailovna USTYUGOV, Yakov Yurevich KORZHAVIN, Dmitriy Valerievich |
| description | The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability. |
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Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. 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Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH |
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