HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodie...

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Hauptverfasser: SOLOVIEV, Valeriy Vladimirovich, NEMANKIN, Timofey Aleksandrovich, MOROZOV, Dmitriy Valentinovich, CHERNYKH, Yulia Sergeevna, GONCHAROVA, Olga Vladimirovna, CHERNOVSKAYA, Tatyana Veniaminovna, SOFRONOVA, Ekaterina Vladimirovna, ULITIN, Andrey Borisovich, IVANOV, Roman Alexeevich, EVDOKIMOV, Stanislav Rudolfovich, EKIMOVA, Victoria Mikhailovna, USTYUGOV, Yakov Yurevich, KORZHAVIN, Dmitriy Valerievich
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.