PROCESSES AND DEVICES FOR DELIVERY OF FLUID BY CHEMICAL REACTION

Processes and devices are disclosed for parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. The device may include a first actuation chamber containing a first reagent, a second reaction...

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Hauptverfasser: HOLLEY, David Arthur, ELLIS, Jeffrey LeClair, TALLARICO, John Paul, BENNISON, Corrie Jo, CHIAPPETTA, Michael Funk, ATTERBURY, William Godwin, PIATT, Beverly Ann, CAIN, Robert Jonathan, LAFEVER, Mark
Format: Patent
Sprache:eng
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Zusammenfassung:Processes and devices are disclosed for parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. The device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.