THERAPEUTIC SIGMA 1 RECEPTOR AGONISTS FOR TREATING LONG QT SYNDROME TYPE 1, TYPE 2, TYPE 6, TYPE 8 AND RELATED CHANNELOPATHIES

The present invention relates to compounds and methods for increasing or agonizing Sigma 1 Receptors and its pathway for treating long QT syndrome (LQTS), and in particular Timothy Syndrome (TS), LQT8, LQT1, LQT2, and LQT6. Additionally, the invention relates to small molecule based therapies and co...

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Bibliographische Detailangaben
Hauptverfasser:	Song, LouJin, Bekdash, Ramsey, Quejada, Jose, Morikawa, Kumi, Yazawa, Masayuki
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds and methods for increasing or agonizing Sigma 1 Receptors and its pathway for treating long QT syndrome (LQTS), and in particular Timothy Syndrome (TS), LQT8, LQT1, LQT2, and LQT6. Additionally, the invention relates to small molecule based therapies and combinations for treating Timothy Syndrome (TS), LQT8, LQT1, LQT2, LQT6 and related channelopathies.