COMPOSITIONS AND METHODS COMPRISING CO-CULTURE OF HEPATOCYTES

Provided are methods and compositions for co-culturing hepatocytes in the presence of growth-arrested stromal cells, resulting in maintenance of hepatocyte function and phenotype for an extended period of time in culture comprising at least 30 days.

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Bibliographische Detailangaben
Hauptverfasser: Roach, Marsha Lynn, Barfield, Shiloh Jesse, Malavarca, Richard Harold
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided are methods and compositions for co-culturing hepatocytes in the presence of growth-arrested stromal cells, resulting in maintenance of hepatocyte function and phenotype for an extended period of time in culture comprising at least 30 days.