QUINOLONE-3-DIARYLETHERS

QUINOLONE-3-DIARYLETHERS

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering t...

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Bibliographische Detailangaben
Hauptverfasser: Kelly, Jane Xu, Doggett, J. Stone, Forquer, Isaac, Li, Yuexin, Stickles, Allison, Smilkstein, Martin, Pou, Sovitj, Bruzual, Igor, Riscoe, Michael, Winter, Rolf, Dodean, Rozalia, Nilsen, Aaron, Bleyle, Lisa, Koop, Dennis, Miley, Galen, Alday, Holland, Frueh, Lisa
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.