Protein Biomarkers for Identifying and Treating Aging Skin and Skin Conditions

Provided are methods of determining the aging of skin or skin disorders or conditions by measuring and evaluating levels of skin-associated biomarker proteins in a subject's skin sample. In aspects, the levels of a subset of biomarker proteins are altered, e.g., increased or decreased, in aging/aged versus non-aging/young skin. Provided are methods for more individualized and direct treatments and therapeutic options for aging skin and/or skin disorders and conditions by determining the levels of those skin biomarker proteins that correlate with aging skin and/or certain skin attributes of a subject and administering treatment products and regimens that result in altering the levels of the biomarker proteins, in particular, toward levels of the proteins in non-aged and healthy skin.