MODULATION OF IFI16 AND STING ACTIVITY

Compounds capable of mimicking the pyrin-domain of IFI16 is provided together with compounds capable of binding to the pyrin-domain of IFI16 or a fragment thereof as well as their uses in medicine. Specifically, the compounds are provided for use in the treatment of disorders associated with STING a...

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Bibliographische Detailangaben
Hauptverfasser:	Jønsson, Kasper Lisager, Paludan, Søren Riis, Jakobsen, Martin Roelsgaard
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds capable of mimicking the pyrin-domain of IFI16 is provided together with compounds capable of binding to the pyrin-domain of IFI16 or a fragment thereof as well as their uses in medicine. Specifically, the compounds are provided for use in the treatment of disorders associated with STING activity, including cancer and immuno-deficient or auto-immune disorders.