SYSTEM AND METHOD FOR NONINVASIVELY ASSESSING BIOENGINEERED ORGANS

SYSTEM AND METHOD FOR NONINVASIVELY ASSESSING BIOENGINEERED ORGANS

Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit configured with software that permits analysis of images acqui...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Czernuszewicz, Tomasz Joseph, Harlacher, Max Stephan, Gessner, Ryan Christopher, Butler, James Owen, O'Connell, Graeme Rainier, Dayton, Paul Alexander
Format: Patent
Sprache:eng
Schlagworte:
ADDITIVE MANUFACTURING TECHNOLOGY
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PERFORMING OPERATIONS
PHYSICS
TESTING
TRANSPORTING
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Beschreibung
Zusammenfassung:Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit configured with software that permits analysis of images acquired from the engineered tissue sample in order to output desired characteristics thereof. In some embodiments, the systems also include a bioreactor for engineering a tissue sample and a pump configured to regulate flow of fluids and reagents into and out of the bioreactor, wherein at least one surface of the bioreactor includes a window that is acoustically transparent to ultrasound waves. Also provided are systems for analyzing cell distribution in an engineered tissue sample and methods for analyzing distribution of cells in an engineered tissue sample present within a bioreactor.