DESIGNER OSTEOGENIC PROTEINS

DESIGNER OSTEOGENIC PROTEINS

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. Th...

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Hauptverfasser: Brown, Christopher Todd, Cain, Michael John, BERASI, Stephen, Calabro, Valerie Perrine, Martinez, Robert Vincent, Seeherman, Howard Joel, Wozney, John Martin, Juo, Zong Sean
Format: Patent
Sprache:eng
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator Brown, Christopher Todd
Cain, Michael John
BERASI, Stephen
Calabro, Valerie Perrine
Martinez, Robert Vincent
Seeherman, Howard Joel
Wozney, John Martin
Juo, Zong Sean
description The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title DESIGNER OSTEOGENIC PROTEINS
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