DESIGNER OSTEOGENIC PROTEINS

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. Th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brown, Christopher Todd, Cain, Michael John, BERASI, Stephen, Calabro, Valerie Perrine, Martinez, Robert Vincent, Seeherman, Howard Joel, Wozney, John Martin, Juo, Zong Sean
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.