METHODS FOR SCREENING CEREBLON MODIFYING COMPOUNDS

METHODS FOR SCREENING CEREBLON MODIFYING COMPOUNDS

A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chamberlain, Philip, Hui, Julia, Stamp, Katherine, Lu, Gang, Sherratt, Philip J, Couto, Suzana Sturlini, Matyskiela, Mary
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.