METHOD TO TREAT ASTHMA AND AIRWAY ALLERGY USING CYCLO TYROSINE-VALINE AND RELATED COMPOUNDS

The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclo tyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperres...

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Bibliographische Detailangaben
Hauptverfasser:	Lin, Chuan-Sheng, Chen, Yu-Li, Lai, Hsin-Chih, Wu, Tsung-Ru, Liau, Jian-Ching, Antig, Luis Dominick B, Chiu, Chen-Yaw, Martel, Jan, Hsieh, Pei-Wen, Chang, Chih-Jung, Lu, Chia-Chen, Ko, Yun-Fei, Young, John D, Ojcius, David Marcelo
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclo tyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresponsiveness, accumulation of immune cells in bronchoalveolar fluid, and allergen-specific antibody production in an animal or human subject. The compound can therefore be used to treat asthma and airway allergy.