METHODS FOR PURIFICATION OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES

METHODS FOR PURIFICATION OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES

Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant region, using Protein A-based...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brown, Paul R, Wood, Andrew M, Tobler, Scott Andreas, Boesch, Austin Wayne
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
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ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant region, using Protein A-based affinity chromatography, are disclosed.