NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS

NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS

wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having αvβ6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PRITCHARD, John Martin, HANCOCK, Ashley Paul, SOLLIS, Steven Leslie, ANDERSON, Niall Andrew, PROCOPIOU, Panayiotis Alexandrou, LEMMA, Seble, CAMPBELL-CRAWFORD, Matthew Howard James
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having αvβ6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an αvβ6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.