SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection.wherein:X is C or N with the proviso that when X is N, R1 does not exist;W is C or N with the proviso that when W is N, R2 does not exist;V is C;E is hydrogen or a pharmaceut...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, Chung-Pin H, LEAHY, David Kenneth, THORAVAL, Dominique, SIRARD, Pierre, ZHANG, Zhongxing, YEUNG, Kap-Sun, KADOW, John F, LEVESQUE, Kathia, UEDA, Yasutsugu, CONNOLLY, Timothy P, MEANWELL, Nicholas A, SOUNDARARAJAN, Nachimuthu, PACK, Shawn K, WANG, Tao
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection.wherein:X is C or N with the proviso that when X is N, R1 does not exist;W is C or N with the proviso that when W is N, R2 does not exist;V is C;E is hydrogen or a pharmaceutically acceptable salt thereof; andY is selected from the group consisting ofAlso, this invention provides for intermediate Compounds II useful in making prodrug Compounds I.wherein:L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.