PROCESS FOR THE PREPARATION OF LEDIPASVIR AND INTERMEDIATES THEREOF

PROCESS FOR THE PREPARATION OF LEDIPASVIR AND INTERMEDIATES THEREOF

The present invention relates to process for preparation of ledipasvir of formula 1 and its novel intermediates. The process involves reaction of compound of formula 2 with compound of formula 3 to yield a compound of formula 4, deprotection of compound of formula 4 to yield compound of formula 5 an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jain, Adinath Murlidhar, Agrawal, Manoj Kunjabihari, Singh, Girij Pal, Deshmukh, Swapnil Sudhakar, Godbole, Himanshu Madhav
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to process for preparation of ledipasvir of formula 1 and its novel intermediates. The process involves reaction of compound of formula 2 with compound of formula 3 to yield a compound of formula 4, deprotection of compound of formula 4 to yield compound of formula 5 and conversion of compound of formula 5 to Ledipasvir wherein PG is an amine protecting group provided that amino protecting group is not carbomethyloxy (-COOCH3) group; X and Y are leaving groups.