VORICONAZOLE INTERMEDIATE AND VORICONAZOLE SYNTHESIS METHOD

VORICONAZOLE INTERMEDIATE AND VORICONAZOLE SYNTHESIS METHOD

Provided is a synthesis method for a voriconazole intermediate condensate as shown in formula II or an acid addition salt thereof. As shown in reaction formula 1, the product is prepared via compounds III and IV. The synthesis method adjusts the feeding means, and the reaction conditions are mild an...

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Bibliographische Detailangaben
Hauptverfasser: Fang, Yuling, Liu, Jiegen, Huang, Wenfeng, Xu, Zhongming, Tu, Guoliang, Meng, Zhaoyang, Huang, Hu, Wu, Qianghui
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided is a synthesis method for a voriconazole intermediate condensate as shown in formula II or an acid addition salt thereof. As shown in reaction formula 1, the product is prepared via compounds III and IV. The synthesis method adjusts the feeding means, and the reaction conditions are mild and controllable, thereby reducing the production of impurity A, avoiding the use of highly toxic metal lead, and eliminating the risk of highly toxic metal remaining in a drug. The product has a higher purity and significant industrial application value.