RHO KINASE INHIBITORS

RHO KINASE INHIBITORS

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compos...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Weimin, Wu, Frank, Bosanac, Todd, Shih, Cheng-Kon, Young, Erick Richard, Kirrane, JR., Thomas Martin, Ginn, John David, Turner, Michael Robert, Prokopowicz, Anthony S, Hickey, Eugene Richard, Schlyer, Sabine K, Snow, Roger John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.