PROCESS FOR MANUFACTURING 1-CYCLOPROPYL-NAPHTHALENES

A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula 1 wherein R 1 -R 7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethyl-ketone with a base and a first solvent to obtain a solution wherei...

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Bibliographische Detailangaben
1. Verfasser: Giselbrecht, Karl-Heinz
Format: Patent
Sprache:eng
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Zusammenfassung:A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula 1 wherein R 1 -R 7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethyl-ketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethyl-ketone is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1 H -pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190°C to obtain the compound of Formula 1.